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Vancomycin has been plagued with concerns about nephrotoxicity since its approval in 1958

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[140] demonstrated that a novel coordination stapled peptide H-histidine-2 (His2)[Pd] consisting of a bis-His peptide based on the H-helix of the cofactor son of sevenless homolog 1 (SOS1) and coordination with Pd(II) can bind to Kirsten rat sarcoma viral oncogene homolog (KRAS) with high binding affinity, which showed a marked increase in the anisotropy when titrated with the preformed coordination stapled peptide to KRAS, while the control peptide H-His2 exhibited lower binding affinity to KRAS